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Contents Vol 66(2)

Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2′-Deoxy and 2′,3′-Dideoxynucleosides

Bo Shen A and Timothy F. Jamison A B
+ Author Affiliations
- Author Affiliations

A Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

B Corresponding author. Email: tfj@mit.edu

Australian Journal of Chemistry 66(2) 157-164 https://doi.org/10.1071/CH12426
Submitted: 16 September 2012  Accepted: 8 October 2012   Published: 19 November 2012

Abstract

A new photochemical flow reactor has been developed for the photo-induced electron-transfer deoxygenation reaction to produce 2′-deoxy and 2′,3′-dideoxynucleosides. The continuous flow format significantly improved both the efficiency and selectivity of the reaction, with the streamlined multi-step sequence directly furnishing the highly desired unprotected deoxynucleosides.


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