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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Hydrophilic Magnetite Nanoparticles Enhance Anticancer Activity of Anthracyclines In Vitro

Bin Yang A , Lin Luo A , Ying Ma A B , Chunyan Chen A , Xiaoming Chen A and Changqun Cai A C
+ Author Affiliations
- Author Affiliations

A Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China.

B Avic Aviation Powerplant Research Institute, Zhuzhou, Hunan 412002, China.

C Corresponding author. Email: cai_mao3@hotmail.com

Australian Journal of Chemistry 69(11) 1247-1253 https://doi.org/10.1071/CH16074
Submitted: 7 February 2016  Accepted: 21 April 2016   Published: 14 June 2016

Abstract

A novel method for enhancing the anticancer activity of anthracyclines in vitro was proposed by using hydrophilic magnetic nanoparticles. Citric acid-coated magnetite nanoparticles Fe3O4 (nano-Fe3O4-CA) interacted with anthracyclines by electrostatic and hydrophobic forces, resulting in the formation of aggregates (nano-Fe3O4-CA-drug). The aggregate was studied by resonance light scattering and fluorescence spectroscopy. The results indicated that in comparison with anthracyclines, the nano-Fe3O4-CA-drug showed high activity towards incorporation in the DNA chain. Furthermore, the cytotoxicity of nano-Fe3O4-CA-drug was investigated by cytotoxicity experiment and cell morphology study. The results confirmed that the nano-Fe3O4-CA-drug could inhibit the growth of cells more effectively than the drug alone. In conclusion, usage of nano-Fe3O4-CA affords reduction of the dosage of anthracyclines in vitro.


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