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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

The reaction of carboxylic acids with epoxides using lithium naphthalenide

T Fujita, S Watanabe and K Suga

Australian Journal of Chemistry 27(10) 2205 - 2208
Published: 1974

Abstract

Lithium naphthalenide reacts with carboxylic acids in the presence of diethylamine to give the α-anions of lithium carboxylates. Reaction of these anions with various epoxides gives the corresponding y-hydroxy acids in good yield. The γ-hydroxy acids easily cyclize to give γ-butyrolactones.

https://doi.org/10.1071/CH9742205

© CSIRO 1974

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