The reaction of β-hydroxy acids with aldehydes
T Fujita, S Watanabe, K Suga, T Isobe and T Miura
Australian Journal of Chemistry
33(3) 685 - 687
β-Hydroxy acids react with various aldehydes in the presence of acidic materials to give spiro lactones in good yields. For example, 2-isopropyl-5-methyl-1,3-dioxaspiro[5,5]undecan-4-one was obtained in 90% yield from the reaction of 2-(1'-hydroxycyclohexyl)propionic acid and isobutyraldehyde.
Full text doi:10.1071/CH9800685
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