Molecular Cocrystals of Carboxylic Acids. XXI. The Role of Secondary Group Interactions in Adduct Formation Between 2-Aminopyrimidine and Substituted Benzoic Acids: the Crystal Structures of the Adducts With o-Phthalic Acid, o-Nitrobenzoic Acid, o-Aminobenzoic Acid and m-Aminobenzoic Acid

Abstract

The crystalline adducts of 2-aminopyrimidine (2-ap) with a series of mainly ortho-substituted benzoic acids, o-phthalic acid ( opht ) [(2-ap)( opht )] (1), 2-nitrobenzoic acid (2-nba) [(2-ap)(2-bna)₂] (2), 2-aminobenzoic acid (2-aba) [(2-aba) [(2-ap)(2-aba)₂] (3) and 3-aminobenzoic acid (3-aba) [(2-ap)(3-aba)] (4) have been prepared and their hydrogen-bonding motifs characterized by using single-crystal X-ray diffraction. The role of substituent groups in secondary associations with cocrystal formation is considered for the 2-aminopyrimidine system.