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RFD is the official journal of the International Embryo Transfer Society and the Society for Reproductive Biology.


Article << Previous     |     Next >>   Contents Vol 18(8)

Genetic modification of somatic cells for producing animal models and for cellular transplantation

Robert B. Norgren

Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, 85805 Nebraska Medical Center, Omaha, NE 68198-5805, USA. Email: rnorgren@unmc.edu
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Great progress has been made in two technologies related to biomedical research: (1) manipulating the genomes of cells; and (2) inducing stem cells in culture to differentiate into potentially useful cell types. These technologies can be used to create animal models of human disease and to provide cells for transplantation to ameliorate human disease. Both embryonic stem cells and adult stem cells have been studied for these purposes. Genetically modified somatic cells provide another source of cells for creating animal models and for cellular transplantation.

Keywords: dedifferentiation, hypoxanthine guanine phosphoribosyl transferase, Lesch–Nyhan’s disease, non-human primate, stem gene targeting.

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