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Interleukin 11: similar or opposite roles in female reproduction and reproductive cancer?

Amy Winship A B , Ellen Menkhorst A , Michelle Van Sinderen A and Evdokia Dimitriadis A B C

A Embryo Implantation Laboratory, MIMR-PHI Institute, 27–31 Wright Street, Clayton, Vic. 3168, Australia.
B Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, Vic. 3800, Australia.
C Corresponding author. Email: evdokia.dimitriadis@princehenrys.org

Reproduction, Fertility and Development - http://dx.doi.org/10.1071/RD14128
Submitted: 11 April 2014  Accepted: 3 July 2014   Published online: 25 August 2014


 
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Abstract

During placental development and carcinogenesis, cell invasion and migration are critical events in establishing a self-supporting vascular supply. Interleukin (IL)-11 is a pleiotropic cytokine that affects the invasive and migratory capabilities of trophoblast cells that form the placenta during pregnancy, as well as various malignant cell types. The endometrium is the site of embryo implantation during pregnancy; conversely, endometrial carcinoma is the most common gynaecological malignancy. Here, we review what is known about the role of IL-11 in trophoblast function and in gynaecological malignancies, focusing primarily on the context of the uterine environment.

Additional keywords: endometrium, placenta, pregnancy, trophoblast.


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