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Vertebrate reproductive science and technology
RESEARCH ARTICLE

Rat and mouse epiblasts differ in their capacity to generate extraembryonic endoderm

Jennifer Nichols, Austin Smith and Mia Buehr

Reproduction, Fertility and Development 10(8) 517 - 526
Published: 1998

Abstract

In this study we have compared the in vitro differentiation potential of epiblast tissue from mouse and rat embryos. Epiblasts were isolated from egg cylinder stage embryos by microdissection and placed in culture. Rat cultures were distinguished by the copious production of parietal endoderm cells. Mouse epiblasts, in contrast, did not produce parietal endoderm. This difference in capacity to regenerate extraembryonic endoderm marks a surprising distinction in development of the pluripotential lineage between these two closely related rodents.

Keywords: egg cylinder, embryonic stem (ES) cells, parietal endoderm.

https://doi.org/10.1071/RD98075

© CSIRO 1998

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