We see how a fundamental physical description, common mathematical formalism, computing methods, modelling and simulation techniques, and computer visualisation help advance our knowledge of living forms through the use of powerful computers and computational methods.

Computational neurophysiology topics cover EEG simulation of cortex, large scale simulation of multi-layer and patchy cortex-like systems, simulation of large scale, anatomically realistic networks of intestinal (enteric) neurons during reflexes and modelling of long-term synaptic potentiation and depression.

A chapter on computers and computations in cognitive science discusses the cognitive systems of computers or dynamical systems. Chapters deal with protein structure prediction and the challenge of genome projects; the prediction of binding peptides utilising experimental binding data and reported binding motifs combined with genetic algorithms and artificial neural networks; application of interactive computer graphics in the analysis of molecular sequences and general issues of successful delivery of computational resources to the users – the biologists. The final seven chapters deal with various aspects of molecular biology, protein biochemistry and bioinformatics.

Preface

Chapters:

1. The Visible Human Project - Male and Female . V. Spitzer
2. Computer-Aided Diagnosis from Medical Images Using Anatomical Models. L. Wilson, M.S. Brown, S.F. Brown, V. Vuwong, B.D. Doust & R.W. Gill
3. Large Scale Computational Simulation of Cortex-like System Using a CRAY YMP Computer. B. Ramsden, G. Egan & R. Siberstein
4. Models of Cerebal Dynamics. J. Wright
5. Large Scale Computational Reconstruction of Enteric Nerve Circuits. J.C. Bornstein
6. Recent Progress in Developing Computational Models of Long-term Potentiation and Depression. C. Coomber
7. Computation and Dynamics in Cognitive Science: An Overview. T. van Gelder
8. Protein Structure Prediction: Meeting the Challenge of Genome Projects. G. Barton
9. Graphical Represenation in Sequence Analysis. G.F. Weiller
10. Delivering the Goods: Putting Solutions to Computational Problems Into the Hands of Biologists. T. Littlejohn
11. Protein Dynamics: Correlation Between NMR Spectroscopy, X-Ray Crystallography and Molecular Dynamics Simulations. C. Lim
12. Molecular Dynamics Simulations of Membrane Proteins. B. Roux
13. Reaction Mechanisms in Enzyme Active Sites Using a Divide and Conquer Approach: Mixed Quantum and Molecular Mechanics (qm/MM). J.E. Gready
14. Hybrid System for Prediction of MHC Class II Binding Peptides. V. Brusic, G. Rudy, J. Hammer, L.C. Harrison

Contributors

Index