Reproduction, Fertility and Development Reproduction, Fertility and Development Society
Vertebrate reproductive science and technology
RESEARCH ARTICLE

Status of human germ cell differentiation from pluripotent stem cells

Renee A. Reijo Pera
+ Author Affiliations
- Author Affiliations

Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305-5463, USA. Email: reneer@stanford.edu

Reproduction, Fertility and Development 25(2) 396-404 https://doi.org/10.1071/RD12047
Submitted: 18 February 2012  Accepted: 31 March 2012   Published: 11 May 2012

Abstract

Historically, the quality of life of infertile couples has been greatly diminished by the loss of opportunity to conceive. However, beginning with the advent of IVF in the late 1970s, novel clinical interventions have greatly changed the outlook for those with severe forms of infertility. Yet, in cases in which the quality and quantity of germ cells are most compromised, there are few options. In the present paper, the current status of germ cell development from stem cells is reviewed in light of potential utility for basic science and clinical applications.

Additional keywords: meiosis, primordial germ cell.


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