The Rangeland Journal The Rangeland Journal Society
Rangeland ecology and management
REVIEW

Characterisation of locoweeds and their effect on livestock production in the western rangelands of China: a review

Hao Lu A , Dan Dan Cao A , Feng Ma A , Shan Shan Wang A , Xiao Wen Yang A , Wen Long Wang A , Qi Wu Zhou A and Bao Yu Zhao A B
+ Author Affliations
- Author Affliations

A College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100 PR China.

B Corresponding author. Email: zhaobaoyu12005@163.com

The Rangeland Journal 36(2) 121-131 https://doi.org/10.1071/RJ13105
Submitted: 29 May 2013  Accepted: 16 December 2013   Published: 20 January 2014

Abstract

The rangelands of China are an important resource for livestock production, and play a strategic role in maintaining ecosystems and protecting the living environment of humans. Drought, overgrazing, infrastructure development, insufficient investment and poor management of rangelands have led to the invasion and spread of poisonous weeds in these rangelands in recent years. The rapid spread of poisonous weeds over the last few decades have caused a series of ecological problems, including a decrease in biological diversity and consequent desertification, and they are seriously affecting the ecological balance of rangelands, and the sustainable livestock production. Locoweeds, which belong to the genera Oxytropis and Astragalus, are an important species of poisonous legumes in the western rangelands of China, causing large economic losses. This review summarises the species and their ecological distribution, the toxic ingredients, the poisoning mechanism of locoweeds and damage control techniques for locoweeds. It attempts to highlight certain issues relating to research on locoweeds and how they are being tackled in order to understand the significance of locoweeds in preserving ecosystem diversity and the steps that require to be taken to control the spread of locoweeds in the western natural rangeland of China.

Additional keywords: biological diversity, damage control techniques, desertification, poisonous weeds, toxins.


References

A, H. L., Dang, G. S., Li, C., Ni, Q. Y., and Lu, Y. B. (1996). Investigation of Oxytropis yellow rust virus in a meadow. Qinghai Prataculturae 5, 41–42. open url image1

Bao, R. Y., Lu, P., He, S., and Qian, Y. G. (2012). Extraction and determination of swainsonine from Oxytropis glabra populations in Hangjin banner. Journal of Inner Mongolia Forestry Science and Technology 38, 30–34. open url image1

Baucom, D. L., Romero, M., Belfon, R., and Creamer, R. (2012). Two new species of Undifilum, fungal endophytes of Astragalus (locoweeds) in the United States. Botany 90, 866–875.
Two new species of Undifilum, fungal endophytes of Astragalus (locoweeds) in the United States.CrossRef | 1:CAS:528:DC%2BC38Xht1Glu7fO&md5=857336633cef42198857c648e9241289CAS | open url image1

Braun, K. (1999). Fungal endophyte infection and swainsonine toxicity in locoweed. MSc Dissertation, New Mexico State University, NM, USA.

Braun, K., Romero, J., Liddell, C., and Creamer, R. (2003). Production of swainsonine by fungal endophytes of locoweed. Mycological Research 107, 980–988.
Production of swainsonine by fungal endophytes of locoweed.CrossRef | 1:CAS:528:DC%2BD3sXms12ntb0%3D&md5=983f08b9ade1311f37af0fb59d38d7f5CAS | 14531620PubMed | open url image1

Burrows, G. E., and Tyrl, R. J. (2001). ‘Toxic Plants of North America.’ (Iowa State University Press: Ames, IA.)

Cao, G. R., Zhang, S. X., and Zhang, Q. Y. (1986). Locoism of sheep in Yulin of Shaanxi and Haiyuan of Ningxia. Journal of Animal Toxicology 1, 18–21. open url image1

Cao, G. R., Li, S. J., Duan, D. X., Liu, N. L., Ma, S. M., Dang, J. H., Zhou, Z. M., Chen, Y. Z., Wang, D. G., Hei, Z. X., and Shi, C. J. (1988). Analysis of the toxic ingredients in Oxytropis ochrocephala. Veterinary Science in China 3, 41–43. open url image1

Cao, G. R., Li, S. J., Duan, D. X., Zhao, X. W., and Russell, J. M. (1989). Isolation and identification of the toxic ingredients from Oxytropis ochrocephala. Journal of Northwest Science-Technology University Agriculture and Forestry (Natural Science Edition) 17, l–7. open url image1

Cao, G. R., Li, S. J., and Zhao, B. Y. (1990). Analysis of Indolizidine alkaloids from locoweed in China. Journal of Animal Toxicology 5, 12–13. open url image1

Chen, S. K., and Sa, R. (1992). Investigation of distribution and harm situation of poisonous plants in desert grassland of Alashan. Chinese Journal of Grasslands 3, 60–62. open url image1

Colegate, S. M., Dorling, P. R., and Huxtable, C. R. (1979). A spectroscopic investigation of swainsonine: an α-mannosidase inhibitor isolated from Swainsona canescens. Australian Journal of Chemistry 32, 2257–2264.
A spectroscopic investigation of swainsonine: an α-mannosidase inhibitor isolated from Swainsona canescens.CrossRef | 1:CAS:528:DyaL3cXnt1Ohsw%3D%3D&md5=11320b65271a0772e24865c056a44722CAS | open url image1

Colodel, E. M., Gardner, D. R., Zlotowski, P., and Driemeier, D. (2002). Identification of swainsonine as a glycoside inhibitor responsible for Sida carpinifolia poisoning. Veterinary and Human Toxicology 44, 177–178.
| 1:CAS:528:DC%2BD38XkvFemtLs%3D&md5=7460bbdd0f8ae78178bc81e4d6ef2006CAS | 12046976PubMed | open url image1

Cook, D., Ralphs, M. H., Welch, K. D., and Stegelmeier, B. (2009a). Locoweed poisoning in livestock. Rangelands 31, 16–21.
Locoweed poisoning in livestock.CrossRef | open url image1

Cook, D., Gardner, D. R., Ralphs, M. H., Pfister, J. A., Welch, K. D., and Green, B. T. (2009b). Swainsoninine concentrations and endophyte amounts of Undifilum oxytropis in different plant parts of Oxytropis sericea. Journal of Chemical Ecology 35, 1272–1278.
Swainsoninine concentrations and endophyte amounts of Undifilum oxytropis in different plant parts of Oxytropis sericea.CrossRef | 1:CAS:528:DC%2BD1MXhsVCqsbvO&md5=3bf2b995771304e0182e1ea5b4a4e5b5CAS | 19904570PubMed | open url image1

Cook, D., Gardner, D. R., Grum, D., Pfister, J. A., Ralphs, M. H., Welch, K. D., and Green, B. T. (2011). Swainsonine and endophyte relationships in Astragalus mollissimus and Astragalus lentiginosus. Journal of Agricultural and Food Chemistry 59, 1281–1287.
Swainsonine and endophyte relationships in Astragalus mollissimus and Astragalus lentiginosus.CrossRef | 1:CAS:528:DC%2BC3MXivFelsg%3D%3D&md5=3f5be0aae338cd5154f69f6a6ab1918aCAS | 21214242PubMed | open url image1

Couch, J. F. (1926). Relative toxicity of lupine alkaloids. Australian Journal of Agricultural Research 32, 51–67.
| 1:CAS:528:DyaB28XhsFWhsw%3D%3D&md5=fe1595ba1d8030dbe82ab1f94a8844b6CAS | open url image1

Crawford, A. C. (1908). ‘Barium, A Cause of the Locoweed Disease.’ USDA, Bureau of Plant Industry Bulletin 129. (USDA: Washington, DC.)

Creamer, R., and Baucom, D. (2013). Fungal endophytes of locoweeds: a commensal relationship? Journal of Plant Physiology and Pathology 1, 1–4. open url image1

Cui, Z. H., Zhao, X. H., Li, Q. F., Wang, J. H., and Geng, G. X. (2008). Determination of swainsonine in Astragalus locoweed by internal standard gas chromatography. Journal of Northwest Science-Technology University Agriculture and Forestry (Natural Science Edition) 36, 17–21.
| 1:CAS:528:DC%2BD1MXhtVams7fO&md5=2c3fb370f909928d81801efb886cead7CAS | open url image1

Dantas, A. F. M., Riet-Correa, F., Gardner, D. R., Medeiros, R. M. T., Barros, S. S., Anjos, B. L., and Lucena, R. B. (2007). Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Turbina cordata in North-eastern Brazil. Toxicon 49, 111–116.
Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Turbina cordata in North-eastern Brazil.CrossRef | 1:CAS:528:DC%2BD28XhtlWqurzO&md5=7910b959aaae4cf1f5f8153f613268b3CAS | open url image1

Davis, T. Z., Lee, S. T., Ralphs, M. H., and Panter, K. E. (2009). Selected common poisonous plants of the United States’ rangelands. Rangelands 31, 38–44.
Selected common poisonous plants of the United States’ rangelands.CrossRef | open url image1

Ding, B. L., Wang, J. C., Xue, D. M., Jia, W. Z., and Wang, S. E. (1994). A study on the pathology of Oxytropis kansuensis intoxication on testes and epididymis of goats. Acta Veterinaire et Zootechnie Sinica 25, 368–374. open url image1

Dong, Y. F., Ding, Y. M., Yu, J., and Jin, Y. M. (1993). Quinolizidine alkaloids from Oxytropis ochrocephala Bunge. Journal of Plant Resources and Environment 2, 58–59.
| 1:CAS:528:DyaK3sXhs1Ghtrw%3D&md5=84b500908df32aa4000a4ae47d6ccbc8CAS | open url image1

Duan, Q. Y., Huang, X. Y., Li, C., Ni, J. M., and Di, D. L. (2010). Pretreatment of sample based on macroporous adsorptive resin and content determination of swainsonine in Oxytropis kansuensis Bunge by HPLC. Analysis and Testing Technology of Instruments 16, 6–10.
| 1:CAS:528:DC%2BC3cXpsFyhurc%3D&md5=9d054cb9979c57b42b68d9e829196a7dCAS | open url image1

Fan, Z. F., Fan, Y. Y., Zhao, B. Y., Wang, Y. C., and Tan, C. J. (2006). Progress in prevention of locoweed poisoning. Heilongjiang Animal Science and Veterinary Medicine 1, 24–25. open url image1

Fraps, G. S. (1936). ‘Locoine, the Poisonous Principle in Locoweed Astragalus earlei.’ (Texas Agriculture Experiment Station: Texas, TX.)

Gao, X. L., Cook, D., Ralphs, M. H., Yan, L., Gardner, D. R., Lee, S. T., Panter, K. E., Han, B., and Zhao, M. L. (2012). Detection of swainsonine and isolation of the endophyte Undifilum from the major locoweeds in Inner Mongolia. Biochemical Systematics and Ecology 45, 79–85.
Detection of swainsonine and isolation of the endophyte Undifilum from the major locoweeds in Inner Mongolia.CrossRef | 1:CAS:528:DC%2BC38XhsFCks7%2FI&md5=4b49fc062e0c711a705228f0104aa1b1CAS | open url image1

Gardner, D. R., Molyneux, R. J., and Ralphs, M. H. (2001). Analysis of swainsonine: extraction methods, detection, and measurement in population of locoweeds (Oxytropis spp.). Journal of Agricultural and Food Chemistry 49, 4573–4580.
Analysis of swainsonine: extraction methods, detection, and measurement in population of locoweeds (Oxytropis spp.).CrossRef | 1:CAS:528:DC%2BD3MXms1Ogu74%3D&md5=34eea300c392af218257ca235445b288CAS | 11599990PubMed | open url image1

Ge, P. B., Zhao, B. Y., Tong, D. W., Qiao, S. Y., Guo, X., Cao, G. R., Zhang, Y. K., and Dong, Q. (2003). Extraction and fractionation and identification of swainsonine on structure from Oxytropis glabra. Chinese Agricultural Science Bulletin 19, 1–4. open url image1

Grum, D. S., Cook, D., Gardner, D. R., Roper, J. M., Pfister, J. A., and Ralphs, M. H. (2012). Influence of seed endophyte amounts on swainsonine concentrations in Astragalus and Oxytropis locoweeds. Journal of Agricultural and Food Chemistry 60, 8083–8089.
Influence of seed endophyte amounts on swainsonine concentrations in Astragalus and Oxytropis locoweeds.CrossRef | 1:CAS:528:DC%2BC38XhtFWhtr%2FN&md5=30b39f43f64c07b915392abb8cc685dcCAS | 22844873PubMed | open url image1

Huang, Y. D., Xiao, G. Z., Meng, J. C., and Kong, F. G. (1992). Isolation and analysis of toxic ingredients from Astragalus variabilis Bunge. Journal of Traditional Chinese Veterinary Medicine 4, 3–6. open url image1

Huang, Y. Q., Zhang, E. R., and Pan, W. F. (2003). Current status of locoweed toxocity. Shandong Science 16, 34–39. open url image1

James, L. F., and Panter, K. E. (1989). Locoweed poisoning in livestock. In: ‘Swainsonine and Related Glycosidase Inhibitors’. (Eds L. F. James, A. D. Elbein, R. J. Molyneux and C. D. Warren.) pp. 23–38. (Iowa State University Press: Ames, IA.)

James, L. F., Shupe, J. L., Binns, W., and Keeler, R. F. (1967). Abortive and teratogenic effects of locoweed on sheep and cattle. American Journal of Veterinary Research 28, 1379–1388.
| 1:STN:280:DyaF1c%2Fht1Gisw%3D%3D&md5=d0ae8020156b1ac17f9b39c9cad6bfd3CAS | 6069571PubMed | open url image1

Karasuno, T., Kanayama, Y., Nishiura, T., Nakao, H., Yonezawa, T., and Tarui, S. (1992). Glycosidase inhibitors (castanospermine and swainsonine) and neuraminidase inhibit pokeweed mitogen-induced B cell maturation. European Journal of Immunology 22, 2003–2008.
Glycosidase inhibitors (castanospermine and swainsonine) and neuraminidase inhibit pokeweed mitogen-induced B cell maturation.CrossRef | 1:CAS:528:DyaK38Xlt12rs7k%3D&md5=63ad0f405d9dcf2e255a5774febee448CAS | 1639102PubMed | open url image1

Lei, Q., and Bei, Z. L. (2009). Study on relationship between the poisonous plants in north-west ethnic regions and ethnoecology. Journal of Anhui Agricultural Sciences 37, 13979–13980. open url image1

Li, J. K. (1990). Research progress on livestock Oxytropis poisoning in China. Journal of Animal Toxicology 5, 17–20. open url image1

Li, J. K. (2000). Study on the ecological engineering control of harms of poisonous plants in Oxytropis sp. at pasture. Transactions of the Chinese Society of Agricultural Engineers 16, 99–102. open url image1

Li, Z. H., and Liu, P. C. (1978). Investigation of Achnatherum Inebrians (Oxytropis glabra) poisoning and its toxic ingredients analysis. Inner Mongolia Animal and Veterinary Medicine 1, 1–17. open url image1

Li, Y. Z., and Nan, Z. B. (2009). Symptomology and etiology of a new disease, yellow stunt, and root rot of standing milkvetch caused by Embellisia sp. in Northern China. Mycopathologia 163, 327–334. open url image1

Li, J. R., Liu, B. Q., Gao, X. Y., and Xu, L. H. (1980). Livestock poisoning investigation and diagnosis of Oxytropis glabra. Xinjiang Agricultural Sciences 4, 37–38. open url image1

Li, J. K., Yang, J. T., Pan, H. P., and Tang, Z. X. (1987). Investigation on livestock poisoning of Oxytropis kansuensis Bunge and Oxytropis ochrocephala Bunge. Veterinary Science in China 5, 22–23. open url image1

Li, J. K., Yang, J. T., and Tang, Z. X. (1988). A study on chemical control methods for Oxytropis ochrocephala. Chinese Journal of Grasslands 3, 8–11. open url image1

Li, Q. F., Wang, J. H., Li, R., Chen, Y., and Liu, Z. B. (2005). Detection of alkaloid and isolation of swainsonine from Oxytropis glacialis. Acta Veterinaire et Zootechnie Sinica 36, 1339–1343. open url image1

Li, Y. Z., Nan, Z. B., and Hou, F. J. (2007). The roles of an Embellisia sp. causing yellow stunt and root rot of Astragalus adsurgens and other fungi in the decline of legume pastures in northern China. Australasian Plant Pathology 36, 397–402.
The roles of an Embellisia sp. causing yellow stunt and root rot of Astragalus adsurgens and other fungi in the decline of legume pastures in northern China.CrossRef | open url image1

Liu, Z. P. (2006). ‘Toxicosis of Animals.’ (China Agriculture Press: Beijing.)

Lu, X. K. (1986). Livestock Oxytropis and Astragalus strictus poisoning. Journal of Animal Toxicology 1, 32–33. open url image1

Lu, P. (2007). ‘Studies on Correlated Factors to Swainsonine in Three Oxytropis Species in Inner Mongolia.’ (Inner Mongolia Agricultural University: Hohhot, China.)

Lu, X. K., and Wang, J. (1982). Investigation of livestock toxic milk vetch poisoning in Nedong of Tibet. Veterinary Science in China 5, 27–29. open url image1

Lu, W., Song, Y. Y., Pong, L., Zhao, B. Y., Lu, H., Rong, J., Ma, Y., Li, R., and Wang, Z. X. (2011). Investigation and control measures on toxic plant disasters on grassland in Alax of Inner Mongolia. Progress in Veterinary Medicine 32, 71–75.
| 1:CAS:528:DC%2BC3MXmtlWmsr0%3D&md5=34f61384b41aa137e6f61c902cd6de1bCAS | open url image1

Lu, H., Wang, S. S., Zhou, Q. W., Zhao, Y. N., and Zhao, B. Y. (2012). Damage and control of major poisonous plants in the western grasslands of China. The Rangeland Journal 34, 329–339.
Damage and control of major poisonous plants in the western grasslands of China.CrossRef | open url image1

Ma, S. J. (2008). The poisonous and harmfulness plant resource in grassland and its economy value in Haixi of Qinghai Province. Pratacultural Science 25, 98–103. open url image1

Ma, Z. H., Zhao, Z. M., and Ren, Q. F. (1994). Two new diseases of yellow hair grazyweed (Oxytropis ochrocephala BGE.). Journal of Ningxia Agricultural College 3, 30–32. open url image1

Ma, S. J., Li, H. Y., Wang, K., Mo, C. H., Zhao, B. Y., and Cao, G. R. (2000). A preventive experiment of Oxytropis poisoning in flocks of grazing sheep by use of ecosystem control project. Progress in Veterinary Medicine 21, 49–51. open url image1

Marsh, C. D. (1909). The locoweed disease of the Plains. USDA, Bureau of Animal Industry Bulletin 112, 15–34. open url image1

Marsh, C. D., Clawson, A. B., and Eggleston, W. W. (1919). The locoweed disease. US Department of Agriculture Bulletin 1054, 1–31. open url image1

Mathews, F. P. (1932). Locoism in domestic animals. Texas Agriculture Experimental Station Bulletin No. 456, Texas.

McDaniel, K. C., Sterling, T., Ivey, S. (2007). Herbicidal control of locoweed. In: ‘Poisonous Plants: Global Research and Solutions’. (Eds K. E. Panter, T. L. Wierenga and J. A. Pfister.) pp. 353–358. (CABI: Wallingford, UK.)

McLain-Romero, J., Creamer, R., Zepeda, H., Strickland, J., and Bell, G. (2004). The toxicosis of Embellisia fungi from locoweed (Oxytropis lambertii) is similar to locoweed toxicosis in rats. Journal of Animal Science 82, 2169–2174.
| 1:CAS:528:DC%2BD2cXlsFWksb8%3D&md5=8eed68b37b2bbc9fe50ebb5d96d6deb7CAS | 15309966PubMed | open url image1

Meng, X. Z., Hu, X. Q., Zhang, R. M., and You, Z. T. (1994). Study on toxic components in O. ochrocephala and O. glabra in Ningxia – Part 1. Toxic alkaloid analysis. Ningxia Journal of Agriculture Forestry Science and Technology 2, 37–40. open url image1

Mezher, H. A., Hough, L., and Richardson, A. (1984). A chiral synthesis of swainsonine from D-Glucose. Journal of the Chemical Society–Chemical Communications , 447–448.
| 1:CAS:528:DyaL2cXltlSqt74%3D&md5=11f51d8d21e922f6fe0f2a4c72449167CAS | open url image1

Ministry of Agriculture of PRC (1996). ‘The Grassland Resources of China.’ Animal Husbandry and Veterinary Department, National Animal Husbandry and Veterinary Station. (China Science and Technology Press: Beijing.)

Molyneux, R. J., and James, L. F. (1982). Loco intoxication: indolizidine alkaloids of spotted locoweed (Astragalus lentiginosus). Science 216, 190–191.
Loco intoxication: indolizidine alkaloids of spotted locoweed (Astragalus lentiginosus).CrossRef | 1:CAS:528:DyaL38XhvFCrsbs%3D&md5=85160a3a9d01974c66db01b28479611bCAS | 6801763PubMed | open url image1

Mukherjee, S., Dawe, A. L., and Creamer, R. (2012). Potential role for saccharopine reductase in swainsonine metabolism in endophytic fungus, Undifilum oxytropis. Fungal Biology 116, 902–909.
Potential role for saccharopine reductase in swainsonine metabolism in endophytic fungus, Undifilum oxytropis.CrossRef | 1:CAS:528:DC%2BC38XhtV2it7jM&md5=99c649c8ffa19a2ab70f50c2c9446761CAS | 22862918PubMed | open url image1

Obeidat, B. S., Strickland, J. R., Vogt, M. L., Loest, C. A., Sawyer, J. E., Reed, M. M., Krehbiel, C. R., Taylor, J. B., Halalsheh, R. A., and Chen, L. (2004). Effects of locoweed on serum constituents and rumen profiles of sheep. Journal of Animal Science 55, 410–414. open url image1

Oldrup, E., McLain-Romero, J., Padilla, A., Moya, A., Gardner, D., and Creamer, R. (2010). Localization of endophytic Undifilum fungi in locoweed seed and influence of environmental parameters on a locoweed in vitro culture system. Botany 88, 512–521.
Localization of endophytic Undifilum fungi in locoweed seed and influence of environmental parameters on a locoweed in vitro culture system.CrossRef | 1:CAS:528:DC%2BC3cXlvVWqu7g%3D&md5=099e6042757e40235d32c9e25b9babe6CAS | open url image1

Patrick, M., Adlard, M. W., and Keshavarz, T. (1993). Production of an indolizidine alkaloid, swainsonine by the filamentous fungus, Metarhizium anisopliae. Biotechnology Letters 15, 997–1000.
Production of an indolizidine alkaloid, swainsonine by the filamentous fungus, Metarhizium anisopliae.CrossRef | 1:CAS:528:DyaK2cXivFCjtg%3D%3D&md5=4104237688668e33ceadad66440bc67aCAS | open url image1

Pfister, A., and Stegelmeier, B. L. (2002). Conditioning taste aversions to locoweed (Oxytropis sericea) in horses. Journal of Animal Science 80, 79–83.
| 1:CAS:528:DC%2BD38XpsFWgsA%3D%3D&md5=3f9b0811b60026007c66d0d774e6c231CAS | open url image1

Pomerinke, M. A., Thompson, D. C., and Clason, D. L. (1995). Bionomics of Cleonidius trivittatus (Coleoptera: Curculionidae): native biological control of purple locoweed (Rosales: Fabaceae). Environmental Entomology 26, 1696–1702. open url image1

Pryor, B. M., Creamer, R., Shoemaker, R. A., McLain-Romero, J., and Hambleton, S. (2009). Undifilum, a new genus for endophytic Embellisia oxytropis and parasitic Helminthosporium bornmuelleri on legumes. Botany 87, 178–194.
Undifilum, a new genus for endophytic Embellisia oxytropis and parasitic Helminthosporium bornmuelleri on legumes.CrossRef | 1:CAS:528:DC%2BD1MXjtlyntbo%3D&md5=d884e0783cb77d089165886640930b9fCAS | open url image1

Ralphs, M. H. (1992). Conditioned food aversion: training livestock to avoid eating poisonous plants. Journal of Range Management 45, 46–51.
Conditioned food aversion: training livestock to avoid eating poisonous plants.CrossRef | open url image1

Ralphs, M. H., and Ueckert, D. N. (1988). Herbicide control of locoweeds: a review. Weed Technology 2, 460–465.
| 1:CAS:528:DyaL1MXlt1yhsw%3D%3D&md5=94ee3598959d12bdb6321a6bd4dd8bf3CAS | open url image1

Ralphs, M. H., Mickelsen, L. V., and Turner, D. L. (1987). Cattle grazing with locoweed: diet selection patterns of native and introduced cattle. Journal of Range Management 40, 333–335.
Cattle grazing with locoweed: diet selection patterns of native and introduced cattle.CrossRef | open url image1

Ralphs, M. H., Mickelsen, L. V., Turner, D. L., and Nielsen, D. B. (1988). Control of white locoweed (Oxytropis sericea). Weed Science 36, 353–358.
| 1:CAS:528:DyaL1cXksFSiurk%3D&md5=91d171ca26b3631b55ffab6f22082400CAS | open url image1

Ralphs, M. H., Monaco, T. A., Valdez, J. R., and Graham, D. (2007). Seeding cool-season grasses to suppress white locoweed (Oxytropis sericea) reestablishment and increase forage production. Weed Technology 21, 661–669.
Seeding cool-season grasses to suppress white locoweed (Oxytropis sericea) reestablishment and increase forage production.CrossRef | 1:CAS:528:DC%2BD2sXhtleqs7zL&md5=43fefd41c3d81f3ef7a630738fd71394CAS | open url image1

Ralphs, M. H., Creamer, R., Baucom, D., Gardner, D. R., Welsh, S. L., Graham, J. D., Hart, C., Cook, D., and Stegelmeier, B. L. (2008). Relationship between the endophyte Embellisia spp. and the toxic alkaloid swainsonine in major locoweed species (Astragalus and Oxytropis). Journal of Chemical Ecology 34, 32–38.
Relationship between the endophyte Embellisia spp. and the toxic alkaloid swainsonine in major locoweed species (Astragalus and Oxytropis).CrossRef | 1:CAS:528:DC%2BD1cXitVGqtLY%3D&md5=4a1fbe4982367886b1a8dc189d57eec3CAS | 18060459PubMed | open url image1

Ren, J. Z. (1954). Several poisonous weeds of grasslands of north-west China. Animal Husbandry and Veterinary Medicine 2, 56–60. open url image1

Reyna, R., Cooke, P., Grum, D., Cook, D., and Creamer, R. (2012). Detection and localization of the endophyte Undifilum oxytropis in locoweed tissues. Botany 90, 1229–1236.
Detection and localization of the endophyte Undifilum oxytropis in locoweed tissues.CrossRef | 1:CAS:528:DC%2BC38Xhs1Klsb%2FO&md5=4c969dc7adf3d01ce31e7fda51126f03CAS | open url image1

Rong, J., Lu, H., Zhao, B. Y., Wang, Z. X., Lu, W. M. Y., and Li, R. (2010). An overview of poisonous plants and their effects on animal husbandry in the United States. Scientia Agricultura Sinica 43, 3633–3644. open url image1

Schneider, M., Ungemach, F., Broquist, H., and Harris, T. (1983). (1S,2R,8R,8aR)-1,2,8- trihydroxyoctahydroindolizine (swainsonine), an a-mannosidase inhibitor from Rhizoctonia leguminicola. Tetrahedron 39, 29–32.
(1S,2R,8R,8aR)-1,2,8- trihydroxyoctahydroindolizine (swainsonine), an a-mannosidase inhibitor from Rhizoctonia leguminicola.CrossRef | 1:CAS:528:DyaL3sXhvFymsrc%3D&md5=864f8aeae84c26c1db5ea6918138e60bCAS | open url image1

Shao, S. X., Zheng, B. S., Zhao, C. Z., Yin, C. Q., Lang, Y. B., and Zhang, A. L. (2004). A study on selenium in Oxytropis and association of it with poisoning of livestock in Hexi corridor. Advances in Earth Sciences 19, 502–505. open url image1

Shen, M. H., Zhao, B. Y., Mo, C. H., Wang, K., Chang, J. J., and Tong, D. W. (2009). The investigation and prevention research of Oxytropis poisonous plants hazard in grassland of Qinghai. Heilongjiang Animal Science and Veterinary Medicine 342, 49–51. open url image1

Stegelmeier, B. L., Molyneux, R. J., Elbein, A. D., and James, L. F. (1995). The lesions of locoweed (Astragalus mollissimus), swainsonine, and castanospermine in rats. Veterinary Pathology 32, 289–298.
The lesions of locoweed (Astragalus mollissimus), swainsonine, and castanospermine in rats.CrossRef | 1:CAS:528:DyaK2MXmt1Gntbs%3D&md5=5d88f785d1f883ffa881c01e81c6c5e7CAS | 7604496PubMed | open url image1

Tan, Y. Y., Hong, Z. P., Guo, Q. H., Gao, J. X., Wang, J. H., and Li, Q. F. (1999). Preliminary studies on the extraction, separation and toxicities of alkaloids from Oxytropis glacialis Benth. ex Bunge collected in Tibet. Journal of Animal Toxicology 14, 22–26. open url image1

Tang, T., Li, Y. L., and Zhou, Q. P. (2007). The preliminary research on Oxytropis ochrocephala rust in alpine meadow around Qinghai lake. Pratacultural Science 24, 84–87. open url image1

Thompson, D. C., Knight, J. L., Sterling, T. M., and Murray, L. W. (1995). Preference for specific varieties of woolly locoweed by a specialist weevil Cleonidius trivittatus. Southwestern Entomology 3, 325–333. open url image1

Tong, D. W., Cao, G. R., and Li, S. J. (2001). Isolation and identification of swainsonine from O. kansuensis Bunge. Journal of Northwest Agriculture and Forestry University (Natural Science Edition) 3, 5–8. open url image1

Tulsiani, D. R., Broquist, H. P., James, L. F., and Touster, O. (1984). The similar effects of swainsonine and locoweed on tissue glycosidases and oligosaccharides of the pig indicate that the alkaloid is the principal toxin responsible for the induction of locoism. Archives of Biochemistry and Biophysics 232, 76–85.
The similar effects of swainsonine and locoweed on tissue glycosidases and oligosaccharides of the pig indicate that the alkaloid is the principal toxin responsible for the induction of locoism.CrossRef | 1:CAS:528:DyaL2cXltVGntbk%3D&md5=3280dede45b568a595048ad0cb052d20CAS | 6430242PubMed | open url image1

van den Elsen, J. M. H., Kuntz, D. A., and Rose, D. R. (2001). Structure of Golgi a-mannosidase II: a target for inhibition of growth and metastasis of cancer cells. The EMBO Journal 20, 3008–3017.
Structure of Golgi a-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.CrossRef | 1:CAS:528:DC%2BD3MXltlaksLc%3D&md5=9705811c0b488b5a5c25d14832a3737aCAS | open url image1

Wang, J. L. (1993). ‘Annals of Epidemic Disease about Domestic Animal and Fowl of Qinghai Province.’ (Gansu Nationalities Publishing House: Gansu, China.)

Wang, J. H., Zhang, Z. H., Zhang, Q., and Gao, J. X. (1998). Report of livestock ‘Achnatherum Inebrians’ poisoning disease in Ali area of Tibet. Journal of Animal Toxicology 13, 22–27. open url image1

Wang, Y. C., Zhao, B. Y., Fan, Y. Y., Fan, Z. F., Tan, C. J., Dong, Q., and Cao, H. (2005). Isolation and identification of swainsonine in Oxytropis kansuensis. Proceedings of Veterinary Medicine 26, 91–93. open url image1

Wang, B. H., CiRen, D. J., Wang, J. L., Zhao, B. Y., Zha, L., and Xiu, H. (2009). Research progress of locoweed in Tibet. Grassland Turf 135, 81–86. open url image1

Wang, S., Chen, G. Y., Hu, J. J., and Ma, C. H. (2011). Determination of swainsonine content in Oxytrpis glabra DC in South Xinjiang by internal standard gas chromatography. Xinjiang Agricultural Sciences 48, 728–733.
| 1:CAS:528:DC%2BC3MXpt1SrtLk%3D&md5=370beedf7c3abfdf119ef99ebd4736d4CAS | open url image1

Xiao, Z. G. (1986). Livestock locoweed poisoning. Veterinary Science in China , 200–202. open url image1

Yang, X. P. (2002). Clinical symptoms of toxicosis in animals by grazyweed. Journal of Wuhan Institute of Science and Technology 15, 25–27.
| 1:CAS:528:DC%2BD38XnvVaqsb8%3D&md5=08b192fccfbaa8041715c34f35b9690cCAS | open url image1

Yang, G. Y., Yang, B. S., and Li, Z. H. (1989). Toxic ingredients and toxicity determination of Oxytropis glabra. Journal of Animal Toxicology 4, 8–10. open url image1

Yao, R. F. (2003). 90% of China’s natural grassland has different degrees of degradation. Pratacultural Science 20, 83. open url image1

Ye, S. J., Liu, J. L., and Huang, W. P. (2009). Progress in the synthesis of anticancer natural product swainsonine. Chinese Journal of Organic Chemistry 29, 689–695.
| 1:CAS:528:DC%2BD1MXosleksb0%3D&md5=5aff6de394005edbcaae59b3e3f8d8e8CAS | open url image1

Yu, R. M., Li, X., and Zhu, T. R. (1989). Structure determination of two new compounds from Oxytropis glabra. Journal of Shenyang Pharmaceutical University 6, 283.
| 1:CAS:528:DyaK3cXlsVyqsLs%3D&md5=8ae574213e517f88426506433a2751aeCAS | open url image1

Yu, Y. T., Wang, J. H., Wang, Y., Song, Y. M., Geng, G. X., and Li, Q. F. (2009). Identification of swainsonine-producing fungal endophytes from three species of locoweeds in Tibet. Scientia Agricultura Sinica 42, 3662–3671.
| 1:CAS:528:DC%2BD1MXhsVSnt7zO&md5=74f3855a644ab370de129e864b973381CAS | open url image1

Zhang, S. Q., and Yan, W. G. (2006). Problems of grassland ecosystems and their countermeasures in western China. Acta Prataculturae Sinica 15, 11–18. open url image1

Zhang, M. S., Gao, Q. D., Hou, D. H., Li, O., Chen, J. M., and Zhu, X. W. (1981). Oxytropis kansuonisis poisoning. Acta Veterinaire et Zootechnie Sinica 3, 145–149. open url image1

Zhao, B. Y. (2001). The systematic analysis and toxic comparative pathology research of locowed (Oxytropis Kansuensis) alkaloid composition. PhD Dissertation, Northwest A&F University, Yangling, China.

Zhao, X. H. (2008). Isolation and identification of swainsonine degrading bacteria and degradation character. MSc Dissertation, Northwest A&F University, Yangling, China.

Zhao, B. Y., and Cao, G. R. (2000). Progress in locoweed poisoning. Journal of Animal Toxicology 15, 19–22. open url image1

Zhao, B. Y., Cao, G. R., Duan, D. X., Li, S. J., Lu, X. K., and Wang, J. B. (1992). Studies on the goats toxicity of Astragalus strictus collected Tibet. Acta Veterinaire et Zootechnie Sinica 23, 276–280. open url image1

Zhao, B. Y., Tong, D. W., Ge, P. B., Dong, Q., and Mo, C. H. (2003). Locoweed harm investigation in the West grassland of China. Chinese Journal of Grasslands 25, 65–68. open url image1

Zhao, B. Y., Chen, S. S., Mo, C. H., Tong, D. W., Wang, K., and Cao, G. R. (2005). A study of extraction and its anti-tumor activity of swainsonine. Journal of Toxicology 19, 252. open url image1

Zhao, B. Y., Wang, J. J., Tan, C. J., Fan, Z. F., and Wang, Y. C. (2006). Isolation and identification of poisonous constituent swainsonine from Astragalus variabilis Bunge. Chinese Journal of Grasslands 28, 66–71. open url image1

Zhao, X. H., Cui, Z. H., Geng, G. X., Wang, J. H., Zhang, Z. M., Song, Y. M., and Liu, Z. B. (2007). Determination of swainsonine in Variation astragalus by the internal standard gas chromatography-methyl-α- D-mannosidase. Chinese Journal of Chromatography 25, 781–782.
| 1:CAS:528:DC%2BD2sXht1SisLrP&md5=0a81f9ef0be26bf011397c337b278897CAS | open url image1

Zhao, B. Y., Liu, Z. Y., Wan, X. P., Huo, X. H., Guo, X., Wang, J. J., Liu, Z. Y., Sun, L. S., and Shi, Z. C. (2008). Damage and control of poisonous-weeds in Chinese Western grassland. Scientia Agricultura Sinica 41, 3094–3103. open url image1

Zhao, B. Y., Wang, B. H., Mo, C. H., Dong, Q., Ge, L., Zha, L., Xiu, H., and Suo, D. (2011). The disaster survey of the Oxytropis glacial is poisoning in livestock in the Ngari of Tibet. Acta Agricultura Boreali-occidentalis Sinica 20, 40–46. open url image1

Zhou, S. Q., Huang, Z. J., and Ma, F. J. (2004). Comprehensive prevention and control methods for the main poisonous plants Oxytropis glabra in Inner Mongolia grassland. Inner Mongolia Science and Technology Economy 21, 49. open url image1

Zhou, Q. W., Bai, S., Lu, H., Zhao, B. Y., and Chen, J. P. (2012). Recent advances and issues on fungal endophyte of locoweed. Pratacultural Science 7, 1049–1057. open url image1



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