
%0 Journal Article
%A Panaretto, BA 
%A Wallace, ALC 
%T Dexamethasone Concentrations in Ovine Plasma During its Intravenous Infusion, its Relation to the Production of Some Endogenous Hormones, and Some of the Effects on Wool Growth
%J Australian Journal of Biological Sciences
%D 1978/06/01
%V 31
%N 3
%P 247-256
%K 
%R https://doi.org/10.1071/BI9780247
%U https://www.publish.csiro.au/paper/BI9780247 
%X Plasma concentrations of dexamethasone have been measured in sheep during an 8-day infusion of dexamethasone-21-phosphate. The dexamethasone concentration profiles generally revealed a reproducible pattern with three phases-a peak during the first 48 h infusion which was followed by falling concentrations during the next 5 days, and a small increase in dexamethasone concentration during the final 24 h infusion was not uncommon. The pattern of dexamethasone concentrations was retained when dosage was arranged in such a way as to infuse increasing quantities of hormonal analogue as infusion progressed. Aspects of the metabolism of the analogue are discussed. 
