
TY  - JOUR
A1  - Panaretto, BA 
A1  - Wallace, ALC 
T1  - Dexamethasone Concentrations in Ovine Plasma During its Intravenous Infusion, its Relation to the Production of Some Endogenous Hormones, and Some of the Effects on Wool Growth
JF  - Australian Journal of Biological Sciences
JO  - Aust. Jnl. Of Bio. Sci.
Y1  - 1978
VL  - 31
IS  - 3
SP  - 247
EP  - 256
KW  - 
UR  - https://doi.org/10.1071/BI9780247 
N2  - Plasma concentrations of dexamethasone have been measured in sheep during an 8-day infusion of dexamethasone-21-phosphate. The dexamethasone concentration profiles generally revealed a reproducible pattern with three phases-a peak during the first 48 h infusion which was followed by falling concentrations during the next 5 days, and a small increase in dexamethasone concentration during the final 24 h infusion was not uncommon. The pattern of dexamethasone concentrations was retained when dosage was arranged in such a way as to infuse increasing quantities of hormonal analogue as infusion progressed. Aspects of the metabolism of the analogue are discussed. 
ER  -

