
%0 Journal Article
%A Smythe, GA 
%A Brandstater, JF 
%A Bradshaw, JE 
%A Lazarus, L 
%T A Simple Procedure for the Assay of Brain Biogenic Amines by Selected-Ion Monitoring: Its Application to the Elucidation of the Mechanism of Prolactin Release Induced by 3-Iodo-L-Tyrosine
%J Australian Journal of Biological Sciences
%D 1979/07/01
%V 32
%N 3
%P 335-342
%K 
%R https://doi.org/10.1071/BI9790335
%U https://www.publish.csiro.au/paper/BI9790335 
%X A simple method for the assay of brain biogenic amines by selected-ion monitoring was applied to examination of the effects of 3-iodo-L-tyrosine on the hypothalamic-median eminence concentrations of dopamine, noradrenaline and serotonin in the rat. Thirty minutes after its administration iodotyrosine (50 mg/kg) caused a highly significant (P < 0·0005) rise in serum prolactin and a highly significant (P < 0·0025) fall in the concentration of dopamine in the hypothalamus and median eminence where the levels reached 50% of control levels. Less marked but significant falls were also observed in the hypothalmic (P < 0·05) and median eminence (P < 0·0025) concentrations of noradrenaline after iodotyrosine administration. Serotonin concentration was significantly reduced (P < 0·025) in the median eminence but not in the hypothalamus after iodotyrosine administration. 
