
%0 Journal Article
%A Oakeshott, JG 
%A Chambers, GK 
%A East, PD 
%A Gibson, JB 
%A Barker, JSF 
%T Evidence for a Genetic Duplication involving Alcohol Dehydrogenase Genes in Drosophila huzzatii and Related Species
%J Australian Journal of Biological Sciences
%D 1982/02/01
%V 35
%N 1
%P 73-84
%K 
%R https://doi.org/10.1071/BI9820073
%U https://www.publish.csiro.au/paper/BI9820073 
%X Drosophila buzzatii has two closely linked loci (0· 4 ± O· 3 cM apart) encoding NAD + -dependent alcohol dehydrogenase. These two loci produce complex, non-overlapping electrophoretic phenotypes and differ in their ontogenetic expression, that of Adh-l relative to Adh-2 being less in adults than in third-instar larvae. Isozymes produced by the two Adh-2 alleles analysed have similar in vitro ADH activity levels, substrate specificities and thermostabilities, whereas the isozymes of the two Adh-l alleles examined differ in ADH activity and specificity for primary versus secondary alcohol substrates. 
