
TY  - JOUR
A1  - Reanney, DC 
A1  - MacPhee, DG 
A1  - Pressing, J 
T1  - Intrinsic Noise and the Design of the Genetic Machinery
JF  - Australian Journal of Biological Sciences
JO  - Aust. Jnl. Of Bio. Sci.
Y1  - 1983
VL  - 36
IS  - 1
SP  - 77
EP  - 90
KW  - 
UR  - https://doi.org/10.1071/BI9830077 
N2  - Darwinian theory envisages 'selection pressure' as a stress imposed on the genotype by the environment. However, noise in the replicative and translational mechanisms in itself imposes a significant 'pressure' on the adaptive fitness of the organism. We propose that the biosphere has been shaped by both extrinsic (environmental) and intrinsic (noise-generated) factors. Because noise has been a remorseless and ever-present background to the evolutionary process, adaptations to this intrinsic pressure include not only a variety of familiar genetic mechanisms but also many anatomical and life-style characteristics that focus on the transmission of information between generations. 
ER  -

