
%0 Journal Article
%A RJones, A 
%A Bubb, WA 
%A Murdoch, SR 
%A Stevenson, DA 
%T Inhibition of Fructolytic Enzymes in Boar Spermatozoa by (S)-a-Chlorohydrin and l-Chloro-3-hydroxypropanone
%J Australian Journal of Biological Sciences
%D 1986/12/01
%V 39
%N 4
%P 395-406
%K 
%R https://doi.org/10.1071/BI9860395
%U https://www.publish.csiro.au/paper/BI9860395 
%X When boar spermatozoa were incubated with the (S)-isomer of the male antifertility agent a-chlorohydrin the activity of glyceraldehyde-3-phosphate dehydrogenase was inhibited. The (R)-isomer had no significant effect on the activity of this enzyme whereas (R,S)-3-chlorolactaldehyde caused an inhibition of its activity and also in that of lactate dehydrogenase. The in vitro production of (S)-3-chlorolactaldehyde, the active metabolite of (S)-a-chlorohydrin, was attempted by incubating boar spermatozoa with l-chloro-3- hydroxypropanone. Preliminary results lead us to propose that this compound is converted into (S)-3- chlorolactaldehyde as well as to another metabolite which is an inhibitor of other enzymes within the fructolytic pathway. 
