
TY  - JOUR
A1  - RJones, A 
A1  - Bubb, WA 
A1  - Murdoch, SR 
A1  - Stevenson, DA 
T1  - Inhibition of Fructolytic Enzymes in Boar Spermatozoa by (S)-a-Chlorohydrin and l-Chloro-3-hydroxypropanone
JF  - Australian Journal of Biological Sciences
JO  - Aust. Jnl. Of Bio. Sci.
Y1  - 1986
VL  - 39
IS  - 4
SP  - 395
EP  - 406
KW  - 
UR  - https://doi.org/10.1071/BI9860395 
N2  - When boar spermatozoa were incubated with the (S)-isomer of the male antifertility agent a-chlorohydrin the activity of glyceraldehyde-3-phosphate dehydrogenase was inhibited. The (R)-isomer had no significant effect on the activity of this enzyme whereas (R,S)-3-chlorolactaldehyde caused an inhibition of its activity and also in that of lactate dehydrogenase. The in vitro production of (S)-3-chlorolactaldehyde, the active metabolite of (S)-a-chlorohydrin, was attempted by incubating boar spermatozoa with l-chloro-3- hydroxypropanone. Preliminary results lead us to propose that this compound is converted into (S)-3- chlorolactaldehyde as well as to another metabolite which is an inhibitor of other enzymes within the fructolytic pathway. 
ER  -

