
%0 Journal Article
%A M Watson, Jaclyn 
%A A MarshalI Graves, Jennifer 
%T Gene Mapping in Marsupials and Monotremes, V. Synteny between Hypoxanthine Phosphoribosyltransferase and Phosphoglycerate Kinase in the Platypus
%J Australian Journal of Biological Sciences
%D 1988/06/01
%V 41
%N 2
%P 231-238
%K 
%R https://doi.org/10.1071/BI9880231
%U https://www.publish.csiro.au/paper/BI9880231 
%X In order to extend comparative mapping studies to the monotreme mammals (subclass Prototheria), somaticcell hybrids were obtained between Chinese-hamster cells deficient in hypoxanthine phosphoribosyltransferase (HPRT) and platypus fibroblasts. The characteristics of these hybrids closely resemble those of metatherian x eutherian hybrids, in that they are recovered at low frequency and they rapidly segregate and fragment platypus chromosomes. Biochemical and cytological studies of the hybrids, their subclones and HPRT-deficient revertants indicate that phosphoglycerate kinase is syntenic with HPRT in the platypus (as it is in other mammals); however, the studies do not permit chromosomal assignment of the syntenic group. The implications of the chromosomal location of this ancient synteny group for the evolution of the mammalian X chromosome are discussed. 
