
%0 Journal Article
%A Faizi, Shaheen 
%A Siddiqui, Bina Shaheen 
%A Saleem, Rubeena 
%A Akhtar, Farzana 
%A Khan, Khursheed Ali 
%A Khan, Shakeel Ahmed 
%A Siddiqui, Salimuzzaman 
%A Parvez, Masood 
%A Choudhary, M. Iqbal 
%T Mannich Reaction Product of Quinolin-8-ol (Oxine) and its Antibacterial Activity
%J Australian Journal of Chemistry
%D 1997/10/14
%V 50
%N 8
%P 861-864
%K 
%R https://doi.org/10.1071/C96056
%U https://www.publish.csiro.au/paper/C96056 
%X Quinolin-8-ol (1) on reaction with 2,6-dichloroaniline and m-nitrobenzaldehyde afforded 7-(&#945;-hydroxy- m-nitrobenzyl)quinolin-8-ol (2), which is an unusual Mannich reaction product. The structure of (2) was determined by spectroscopic and single-crystal X-ray diffraction studies. Preliminary antimicrobial screening showed that (1) and (2) have activity against a large number of Gram-positive and Gram-negative bacteria. 
