
%0 Journal Article
%A Barlin, Gordon B. 
%A Davies, Les P. 
%A Harrison, Peter W. 
%T Imidazo[1,2-<emph type="2">b</emph>]pyridazines. XXI. Syntheses of some 3-Acylaminomethyl-6-(chloro and iodo)- 2-(substituted phenyl)-imidazo[1,2-<emph type="2">b</emph>]pyridazines and -imidazo[1,2-<emph type="2">a</emph>]pyridines and their Interaction with Central and Mitochondrial Benzodiazepine
%J Australian Journal of Chemistry
%D 1997/03/05
%V 50
%N 1
%P 61-68
%K 
%R https://doi.org/10.1071/C96130
%U https://www.publish.csiro.au/paper/C96130 
%X A series of 3-acylaminomethyl-6-(chloro, iodo and methyl)-2-(phenyl, 4&#8242;-t-butylphenyl, 4&#8242;-cyclohexyl- phenyl, biphenyl-4&#8242;-yl, 4&#8242;-chlorophenyl and 4&#8242;-iodophenyl)imidazo&#91;1,2-b&#93;pyridazines and imidazo&#91;1,2- a&#93;pyridines has been prepared and examined for interaction with central and mitochondrial (peripheral- type) benzodiazepine receptors. The imidazo&#91;1,2-b&#93;pyridazines were generally more selective for the mitochondrial receptors than the corresponding imidazo&#91;1,2-a&#93;pyridines. Of these compounds, 3- acetamidomethyl-2-(biphenyl-4&#8242;-yl)-6-chloroimidazo&#91;1,2-b&#93;pyridazine (9) proved to be the most selective in studies of the displacement of &#91;3H&#93;diazepam from peripheral-type and central benzodiazepine receptors (IC50 2&#183;8 nM and 0% displacement at 1000 nM, respectively). 
