
TY  - JOUR
A1  - Barlin, Gordon B. 
A1  - Davies, Les P. 
A1  - Harrison, Peter W. 
T1  - Imidazo[1,2-<emph type="2">b</emph>]pyridazines. XXI. Syntheses of some 3-Acylaminomethyl-6-(chloro and iodo)- 2-(substituted phenyl)-imidazo[1,2-<emph type="2">b</emph>]pyridazines and -imidazo[1,2-<emph type="2">a</emph>]pyridines and their Interaction with Central and Mitochondrial Benzodiazepine
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1997
VL  - 50
IS  - 1
SP  - 61
EP  - 68
KW  - 
UR  - https://doi.org/10.1071/C96130 
N2  - A series of 3-acylaminomethyl-6-(chloro, iodo and methyl)-2-(phenyl, 4&#8242;-t-butylphenyl, 4&#8242;-cyclohexyl- phenyl, biphenyl-4&#8242;-yl, 4&#8242;-chlorophenyl and 4&#8242;-iodophenyl)imidazo&#91;1,2-b&#93;pyridazines and imidazo&#91;1,2- a&#93;pyridines has been prepared and examined for interaction with central and mitochondrial (peripheral- type) benzodiazepine receptors. The imidazo&#91;1,2-b&#93;pyridazines were generally more selective for the mitochondrial receptors than the corresponding imidazo&#91;1,2-a&#93;pyridines. Of these compounds, 3- acetamidomethyl-2-(biphenyl-4&#8242;-yl)-6-chloroimidazo&#91;1,2-b&#93;pyridazine (9) proved to be the most selective in studies of the displacement of &#91;3H&#93;diazepam from peripheral-type and central benzodiazepine receptors (IC50 2&#183;8 nM and 0% displacement at 1000 nM, respectively). 
ER  -

