
%0 Journal Article
%A Hughes, Robert 
%A Prager, Rolf H. 
%T Potential GABA<emph tye="8">B</emph> Receptor Antagonists. VIII. The Synthesis of 3-Amino-<emph type="2">N</emph>-aryl-2-hydroxy- propane-1-sulfonamides and Analogues of Baclofen Containing Nitro Groups
%J Australian Journal of Chemistry
%D 1997/03/05
%V 50
%N 1
%P 19-26
%K 
%R https://doi.org/10.1071/C96149
%U https://www.publish.csiro.au/paper/C96149 
%X 3-Amino-N-aryl-2-hydroxypropane-1-sulfonamides were synthesized by the reaction of the corresponding epoxy sulfonamide with sodium azide, followed by reduction to the corresponding amine. The synthesis of 3-nitropropan-1-amine and two 2-thienyl derivatives is also reported. 3-Amino-2-hydroxy-N-(4-nitrophenyl)propane-1-sulfonamide and 3-nitropropan-1-amine were found to be specific antagonists of GABA at the GABAB receptor. Substitution of the amino group by alkyl or aryl groups reduced the activity. 
