
TY  - JOUR
A1  - Ang, Siau-Gek 
A1  - Peh, Yoke-Keow 
T1  - Binding Studies on Modified Vancomycin
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1997
VL  - 50
IS  - 1
SP  - 31
EP  - 34
KW  - 
UR  - https://doi.org/10.1071/C96172 
N2  - Binding studies were carried out on a vancomycin derivative to examine its potential bactericidal activity. Of particular interest was the effect of dimethylation of the amino group at the N-terminus of vancomycin on the binding ability of the antibiotic to bacterial cell-wall peptide analogues, namely Ac-D-Ala-D-Ala and Ac2-L-Lys-D-Ala-D-Ala. Reductive methylation was carried out with sodium cyanoborohydride and formaldehyde, and the binding constants of the vancomycin derivative with the peptides were measured by ultraviolet difference spectroscopy. 
ER  -

