
%0 Journal Article
%A Abbenante, Giovanni 
%A Hughes, Robert 
%A Prager, Rolf H. 
%T Potential GABA <emph tye="8">B</emph> Receptor Antagonists. IX The Synthesis of 3-Amino-3-(4-chlorophenyl)propanoic Acid, 2-Amino-2-(4-chlorophenyl)ethylphosphonic Acid and 2-Amino-2-(4-chlorophenyl)ethanesulfonic Acid
%J Australian Journal of Chemistry
%D 1997/08/19
%V 50
%N 6
%P 523-528
%K 
%R https://doi.org/10.1071/C96216
%U https://www.publish.csiro.au/paper/C96216 
%X This paper describes the synthesis of 3-amino-3-(4-chlorophenyl)propanoic acid and the corresponding phosphonic and sulfonic acids, lower homologues of baclofen, phaclofen and saclofen respectively. The chlorinated acids were all weak specific antagonists of GABA at the GABAB receptor, with the sulfonic acid (pA2 4&#183;0) being stronger than the phosphonic acid (pA2 3&#183;8) and carboxylic acid (pA2 3&#183;5). 
