
TY  - JOUR
A1  - Abbenante, Giovanni 
A1  - Hughes, Robert 
A1  - Prager, Rolf H. 
T1  - Potential GABA <emph tye="8">B</emph> Receptor Antagonists. IX The Synthesis of 3-Amino-3-(4-chlorophenyl)propanoic Acid, 2-Amino-2-(4-chlorophenyl)ethylphosphonic Acid and 2-Amino-2-(4-chlorophenyl)ethanesulfonic Acid
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1997
VL  - 50
IS  - 6
SP  - 523
EP  - 528
KW  - 
UR  - https://doi.org/10.1071/C96216 
N2  - This paper describes the synthesis of 3-amino-3-(4-chlorophenyl)propanoic acid and the corresponding phosphonic and sulfonic acids, lower homologues of baclofen, phaclofen and saclofen respectively. The chlorinated acids were all weak specific antagonists of GABA at the GABAB receptor, with the sulfonic acid (pA2 4&#183;0) being stronger than the phosphonic acid (pA2 3&#183;8) and carboxylic acid (pA2 3&#183;5). 
ER  -

