
%0 Journal Article
%A Schmitt, Martine 
%A Bourguignon, Jean-Jacques 
%A Barlin, Gordon B. 
%A Davies, Les P. 
%T Imidazo[1,2-<emph type="2">b</emph>]pyridazines. XXIII Some 5-Deaza Analogues. Syntheses of Some 2-Aryl-6-(chloro, methoxy or unsubstituted)-3- (variously substituted)imidazo[1,2-<emph type="2">a</emph>]pyridines and Their Affinity for Central and Mitochondrial Benzodiazepine Receptor
%J Australian Journal of Chemistry
%D 1997/09/05
%V 50
%N 7
%P 719-726
%K 
%R https://doi.org/10.1071/C97004
%U https://www.publish.csiro.au/paper/C97004 
%X The syntheses of ethyl &#123;2&#8242;-aryl-6&#8242;-(chloro, methoxy and unsubstituted)imidazo&#91;1,2-a&#93;pyridin-3&#8242;-yl&#125;-2- (acylamino, acetoxy and hydroxy)acetates, 3-benzamidomethyl-2-benzoyl-6-(chloro and methoxy)imidazo-&#91;1,2-a&#93;pyridines, 3-amino-6-chloro-2-phenylimidazo&#91;1,2-a&#93;pyridine and ethyl 2-(2&#8242;-phenylimidazo&#91;1,2-a&#93;pyridin-3&#8242;-yl)acetate are reported. The ability of these compounds to displace &#91;3H&#93;diazepam from central and mitochondrial (peripheral-type) benzodiazepine receptors has been examined. Ethyl 2-benzamido-2-&#123;6&#8242;-chloro-2&#8242;-(4&#8242;&#8242;-chlorophenyl)imidazo&#91;1,2-a&#93;pyridin-3&#8242;-yl&#125; acetate (21) was selective for peripheral-type receptors (IC5013 nM) but none bound strongly to central receptors. 
