
%0 Journal Article
%A Easton, Christopher J. 
%A Lincoln, Stephen F. 
%A May, Bruce L. 
%A Papageorgiou, John 
%T Reactions of Amino-Substituted Cyclodextrins with 2-Arylpropanoic Acid Derivatives
%J Australian Journal of Chemistry
%D 1997/07/07
%V 50
%N 5
%P 451-456
%K 
%R https://doi.org/10.1071/C97034
%U https://www.publish.csiro.au/paper/C97034 
%X Reactions of 6A-amino-6A-deoxy-&#946;-cyclodextrin and 3A-amino-3A-deoxy-(2AS,3AS)-&#946;-cyclodextrin with the 3-nitrophenyl esters of 2-phenylpropanoic acid and Ibuprofen occur with only low diastereoselectivity, to afford the corresponding arylpropanamido-substituted cyclodextrins. These amides are also formed by decarboxylation of corresponding malonates, again with only low diastereoselectivity. The n.m.r. spectra of the amido-substituted cyclodextrins indicate that the aryl substituent is included within the cyclodextrin annulus at low temperature, but becomes dissociated from the cavity as the temperature is increased. 
