
TY  - JOUR
A1  - Easton, Christopher J. 
A1  - Lincoln, Stephen F. 
A1  - May, Bruce L. 
A1  - Papageorgiou, John 
T1  - Reactions of Amino-Substituted Cyclodextrins with 2-Arylpropanoic Acid Derivatives
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1997
VL  - 50
IS  - 5
SP  - 451
EP  - 456
KW  - 
UR  - https://doi.org/10.1071/C97034 
N2  - Reactions of 6A-amino-6A-deoxy-&#946;-cyclodextrin and 3A-amino-3A-deoxy-(2AS,3AS)-&#946;-cyclodextrin with the 3-nitrophenyl esters of 2-phenylpropanoic acid and Ibuprofen occur with only low diastereoselectivity, to afford the corresponding arylpropanamido-substituted cyclodextrins. These amides are also formed by decarboxylation of corresponding malonates, again with only low diastereoselectivity. The n.m.r. spectra of the amido-substituted cyclodextrins indicate that the aryl substituent is included within the cyclodextrin annulus at low temperature, but becomes dissociated from the cavity as the temperature is increased. 
ER  -

