
TY  - JOUR
A1  - Croft, Anna K. 
A1  - Easton, Christopher J. 
A1  - Lincoln, Stephen F. 
A1  - May, Bruce L. 
A1  - Papageorgiou, John 
T1  - An H.P.L.C. Study of Cooperative Guest Binding by a Covalently Linked <font face="symbol">b</font>-Cyclodextrin Dimer
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1997
VL  - 50
IS  - 8
SP  - 857
EP  - 860
KW  - 
UR  - https://doi.org/10.1071/C97045 
N2  - The complexation of the anions of Methyl Orange (MO&#175;) (1) and Indomethacin (Ind-) (2) by the &#946;-cyclodextrin dimer (3) has been studied by means of high-performance liquid chromatography. The cyclodextrin annuli are shown to jointly act as a single binding site for complexation of MO&#175; (1). Thus the association constants of (3&#183;3&#177;0&#183;3) &#215; 103 and (220&#177;20) &#215; 103 dm3 mol&#8722;1 for the 1 : 1 complexes with &#946;-cyclodextrin and the dimer (3), respectively, indicate very strong cooperative binding by the annuli of the linked species. By contrast, the complexation of Ind&#175; (2) by the cyclodextrin dimer (3) is characterized by two independent binding sites. This lack of cooperative binding is reflected in the association constant for the 1 : 1 complex in each binding site, which at (1&#183;3&#177;0&#183;1) &#215; 103 dm3 mol&#8722;1 is little greater than that of (0&#183;7&#177;0&#183;05) &#215; 103dm3 mol&#8722;1 for the complex with &#946;-cyclodextrin. 
ER  -

