
%0 Journal Article
%A Tate, Max E. 
%A Delaere, Ian M. 
%A Jones, Graham P. 
%A Seawright, Alan A. 
%A Tiekink, Edward R. T. 
%T Crystal and Molecular Structure and Biological Activity of <emph type="2">Z</emph>)-(Benzoyloxymethyl-<emph type="2">NNO-azoxy</emph>)methane
%J Australian Journal of Chemistry
%D 1997/09/05
%V 50
%N 7
%P 771-774
%K 
%R https://doi.org/10.1071/C97053
%U https://www.publish.csiro.au/paper/C97053 
%X Characterization of (benzoyloxymethyl-NNO-azoxy)methane, from benzoylation of the cycasin aglycone methylazoxymethanol, commonly referred to as MAM, is reported. Crystal structure analysis shows that the azoxy substituents have the Z configuration. Crystals are monoclinic, space group P21/c, a 7&#183;436(2), b 8&#183;771(2), c 14&#183;640(1) &#197;, &#946; 90&#183;73(1)&#176;, Z 4; the structure was refined to final R 0&#183;048 by using 1171 reflections with I &#x2265; 3&#183;0&#963;(I ). Subcutaneous injection of (Z)-(benzoyloxymethyl-NNO-azoxy)methane in mice showed liver changes typical of the corresponding MAM acetate-induced hepatotoxicity. This permits correlation of hepatotoxic effects with the Z configuration of the aglycone. Histological examination of the brain and spinal cord revealed no significant changes at a dosage of 52&#183; 6 mg/kg. 
