
TY  - JOUR
A1  - Tate, Max E. 
A1  - Delaere, Ian M. 
A1  - Jones, Graham P. 
A1  - Seawright, Alan A. 
A1  - Tiekink, Edward R. T. 
T1  - Crystal and Molecular Structure and Biological Activity of <emph type="2">Z</emph>)-(Benzoyloxymethyl-<emph type="2">NNO-azoxy</emph>)methane
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1997
VL  - 50
IS  - 7
SP  - 771
EP  - 774
KW  - 
UR  - https://doi.org/10.1071/C97053 
N2  - Characterization of (benzoyloxymethyl-NNO-azoxy)methane, from benzoylation of the cycasin aglycone methylazoxymethanol, commonly referred to as MAM, is reported. Crystal structure analysis shows that the azoxy substituents have the Z configuration. Crystals are monoclinic, space group P21/c, a 7&#183;436(2), b 8&#183;771(2), c 14&#183;640(1) &#197;, &#946; 90&#183;73(1)&#176;, Z 4; the structure was refined to final R 0&#183;048 by using 1171 reflections with I &#x2265; 3&#183;0&#963;(I ). Subcutaneous injection of (Z)-(benzoyloxymethyl-NNO-azoxy)methane in mice showed liver changes typical of the corresponding MAM acetate-induced hepatotoxicity. This permits correlation of hepatotoxic effects with the Z configuration of the aglycone. Histological examination of the brain and spinal cord revealed no significant changes at a dosage of 52&#183; 6 mg/kg. 
ER  -

