
%0 Journal Article
%A Bagnell, Laurence 
%A Bliese, Marianne 
%A Cablewski, Teresa 
%A Strauss, Christopher R. 
%A Tsanaktsidis, John 
%T Environmentally Benign Procedures for the Preparation and Isolation of 3-Methylcyclopent-2-en-1-one
%J Australian Journal of Chemistry
%D 1997/11/15
%V 50
%N 9
%P 921-926
%K 
%R https://doi.org/10.1071/C97097
%U https://www.publish.csiro.au/paper/C97097 
%X A moderately yielding (50&#177;4%) method for obtaining 3-methylcyclopent-2-en-1-one from hexane-2,5-dione in &#x2265;99&#183;5% purity was developed, using 2&#183;1% (w/v) of aqueous KOH at reflux. However, the yield was increased to 80&#177;5% by using considerably lower concentrations of base (&#60;0&#183;1%) and higher temperature (200&#176;C) with a conventionally heated autoclave or a microwave batch reactor. The preparation was scaled up with a larger autoclave and also with a continuous flow microwave reactor. The dione impurity was removed from the enone by preferential adsorption on an anion-exchange resin in the bisulfite form. The product was recovered from the aqueous phase with a hydrophobic resin. This environmentally benign, non-extractive isolation method has potential for broad applicability in cleaner production. 
