
%0 Journal Article
%A Clark, Christopher I. 
%A Kelly, David P. 
%A Martin, Roger F. 
%A White, Jonathan M. 
%A Lobachevsky, Pavel 
%T Synthesis and Binding Studies of a New DNA Minor Groove Binder
%J Australian Journal of Chemistry
%D 1998/04/16
%V 51
%N 3
%P 243-248
%K 
%R https://doi.org/10.1071/C97115
%U https://www.publish.csiro.au/paper/C97115 
%X 2-&#91;2&#8242;-(4&#8242;&#8242;-Ethoxyphenyl)-1H-indol-6&#8242;-yl&#93;-5-(4&#8242;&#8242;&#8242;-methylpiperazin-1&#8242;&#8242;&#8242;-yl)-1H-benzimidazole (1) has been synthesized from 2-(4&#8242;-ethoxyphenyl)-1H-indole-6-carbaldehyde (4b) and 4-(4&#8242;-methylpiperazin-1&#8242;-yl)benzene-1,2-diamine (3b). The aldehyde (4b) was prepared in five steps by using a modified Leimgruber&#8211;Batcho indole synthesis. Evaluation of (1) as a DNA ligand is described. 
