
%0 Journal Article
%A Abell, Andrew D. 
%A Phillips, Andrew J. 
%A Budhia, Sangeeta 
%A McNulty, Ann M. 
%A Neubauer, Blake L. 
%T The Preparation and Biological Activity of Lactam-Based, Non-Steroidal, Inhibitors of Human Type-1 Steroid 5&#945;-Reductase.
%J Australian Journal of Chemistry
%D 1998/05/20
%V 51
%N 5
%P 389-396
%K 
%R https://doi.org/10.1071/C97130
%U https://www.publish.csiro.au/paper/C97130 
%X A Beckmann rearrangement of cis- and trans-fused 3,4,4a,9,10,10a-hexahydrophenanthren-1(2H)-one oximes has yielded three azepines. An in vitro assay of the azepines and (3aSR,9bSR)-6-methoxy-3-methyl-1,3,3a,4,5,9b-hexahydro-2H-benz&#91;e&#93;indol-2-one, prepared in four steps from naphthalene-1,6-diol, against human type-1 steroid 5&#945;-reductase, revealed the tricyclic five-membered lactam to be a potent inhibitor (IC50 733 nM). 
