
%0 Journal Article
%A Yuasa, Yoko 
%A Yuasa, Yoshifumi 
%A Tsuruta, Haruki 
%T The Synthesis of (<emph type="2">S</emph>)-3-Acetylthio-2-benzylpropionic Acid from (<emph type="2">Z</emph>)-2-Chloromethyl-3-phenylprop-2-enoic Acid by Asymmetric Hydrogenation: a Chiral Building Block of an Enkephalinase Inhibitor
%J Australian Journal of Chemistry
%D 1998/06/03
%V 51
%N 6
%P 511-514
%K 
%R https://doi.org/10.1071/C97141
%U https://www.publish.csiro.au/paper/C97141 
%X (S)-2-Benzyl-3-chloropropionic acid (7) was synthesized from (Z)-2-(chloromethyl)-3-phenylprop-2-enoic acid (5) by asymmetric hydrogenation with a ruthenium 2,2&#8242;-bis(di-p-tolylphosphino)-1,1&#8242;-binaphthyl complex in the presence of triethylamine. Acetylthiolation then gave 3-acetylthio-2-benzylpropionic acid (2), a subunit of the enkephalinase inhibitor thiorphan (1). 
