
%0 Journal Article
%A Fares, Fares A. 
%A Ridley, Damon D. 
%A Yin, Ping 
%T Sulfonamide Analogues of Creatinine. The Synthesis of 3-Amino-4,5-dihydro-1,2,4-thiadiazole 1,1-Dioxides from Base-Induced Cyclization Reactions
%J Australian Journal of Chemistry
%D 1997/12/15
%V 50
%N 10
%P 1027-1030
%K 
%R https://doi.org/10.1071/C97159
%U https://www.publish.csiro.au/paper/C97159 
%X We report the preparation of 3-amino-4,5-dihydro-1,2,4-thiadiazole 1,1-dioxide and of its 4-methyl derivative which are of interest as potential analogues of creatinine. The thiadiazoles are obtained from chloromethylsulfonylation ofS-benzylisothiourea, followed by cyclization of the chloromethanesulfonamide under basic conditions in the presence of 2-(t-butoxycarbonyloxyimino)-2-phenylacetonitrile or of methyl iodide. 
