
TY  - JOUR
A1  - Fares, Fares A. 
A1  - Ridley, Damon D. 
A1  - Yin, Ping 
T1  - Sulfonamide Analogues of Creatinine. The Synthesis of 3-Amino-4,5-dihydro-1,2,4-thiadiazole 1,1-Dioxides from Base-Induced Cyclization Reactions
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1997
VL  - 50
IS  - 10
SP  - 1027
EP  - 1030
KW  - 
UR  - https://doi.org/10.1071/C97159 
N2  - We report the preparation of 3-amino-4,5-dihydro-1,2,4-thiadiazole 1,1-dioxide and of its 4-methyl derivative which are of interest as potential analogues of creatinine. The thiadiazoles are obtained from chloromethylsulfonylation ofS-benzylisothiourea, followed by cyclization of the chloromethanesulfonamide under basic conditions in the presence of 2-(t-butoxycarbonyloxyimino)-2-phenylacetonitrile or of methyl iodide. 
ER  -

