
%0 Journal Article
%A Teo, Chih-Lynne 
%A Fenton, Ronald R. 
%A Turner, Peter 
%A Hambley, Trevor W. 
%T The Dichloroplatinum(II) Complex of 5,5,7-Trimethyl-1,4-diazacycloheptane: Preparation, Crystal Structure and Binding to Nucleotides and DNA
%J Australian Journal of Chemistry
%D 1998/11/17
%V 51
%N 11
%P 977-984
%K 
%R https://doi.org/10.1071/C97176
%U https://www.publish.csiro.au/paper/C97176 
%X The preparation of &#91;Pt(tmdz)Cl2&#93; (tmdz = 5,5,7-trimethyl-1,4-diazacycloheptane) is described. The crystal structure has been determined by X-ray diffraction methods and refined to an R value of 0&#183;048 (764F). The crystals are triclinic, space group P -1, a 8&#183;023(2), b 10&#183;874(4), c 14&#183;207(3) &#197;, &#945; 95&#183;34(3), &#946; 94&#183;96(2), &#947; 94&#183;97(3)&#176;. N.m.r. studies and molecular mechanics methods show that only one diastereomer of the complex&#8212;that observed in the crystal structure&#8212;is energetically accessible. In total DNA binding studies, &#91;Pt(tmdz)Cl2&#93; binds less effectively and at a lower rate than cisplatin. The complex reacts with dG and d(GpG) to form a variety of isomeric products, as indicated by h.p.l.c. analysis. 
