
TY  - JOUR
A1  - Guzzo-Pernell, Nancy 
A1  - Lawlor, John M. 
A1  - Tregear, Geoffrey W. 
A1  - Haralambidis, Jim 
T1  - Triplex Formation by an Oligonucleotide Containing the Novel Modified Nucleoside 2&#8242;-Deoxy-<emph type="2">N</emph><emph type="7">4</emph>-phenylcarbamoylcytidine
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1998
VL  - 51
IS  - 11
SP  - 965
EP  - 972
KW  - 
UR  - https://doi.org/10.1071/C98062 
N2  - 2&#8242;-Deoxy-N4-phenylcarbamoylcytidine (Pc) was designed for triplex recognition of the cytosine&#123;guanine base pair at physiological pH values to assist in the development of triplex-forming oligomers. Thermal denaturation of a triplex mixture in which the third strand incorporated Pc as a central nucleoside showed that, at pH 6&#183;1, Pc binds selectively&#8212;though weakly&#8212;to the target cytosine&#8212;guanine and also to guanine&#8212;cytosine; but the gel mobilities of the same mixtures indicate the possibility of specificity for the target cytosine-guanine base pair at pH values higher than 6&#183;1. The result may provide leads useful in the development of improved triplex-forming oligomers. 
ER  -

