
%0 Journal Article
%A Katsifis, Andrew G. 
%A McPhee, Meredith E. 
%A Ridley, Damon D. 
%T Hydride Reductions of 1<emph type="2">H</emph>-Pyrrolo[2,1-c][1,4]-benzodiazepine-5,11-diones: Selective Reduction of Secondary Amides to Carbinolamines
%J Australian Journal of Chemistry
%D 1999/12/04
%V 51
%N 12
%P 1121-1130
%K 
%R https://doi.org/10.1071/C98079
%U https://www.publish.csiro.au/paper/C98079 
%X For the syntheses of radiolabelled pyrrolo&#91;1,4&#93;benzodiazepine antitumour antibiotics we required a method in which the unstable carbinolamine functionality was introduced prior to the radiolabel. In turn this required the selective reduction of a secondary amide in the presence of, inter alia, a tertiary amide. We report methods which can be used to achieve this outcome in a series of 1H-pyrrolo&#91;2,1-c&#93;&#91;1,4&#93;benzodiazepine-5,11-diones. 
