
%0 Journal Article
%A Strauss, Christopher R. 
%T Invited Review. A Combinatorial Approach to the Development of Environmentally Benign Organic Chemical Preparations
%J Australian Journal of Chemistry
%D 1999/02/19
%V 52
%N 2
%P 83-96
%K 
%R https://doi.org/10.1071/C98156
%U https://www.publish.csiro.au/paper/C98156 
%X Enabling technologies and methodologies were established and combined to afford various environmentally benign processes for laboratory-scale organic synthesis and for the production of fine chemicals, intermediates and pharmaceuticals. The technologies comprised continuous and batch microwave reactors and catalytic membranes. The methodologies included solvent-free conditions, catalysed or uncatalysed processes, the use of aqueous media at high temperature and non-extractive techniques for product isolation. Applications included Hofmann eliminations, Willgerodt and Jacobs&#8211;Gould reactions, indole transformations, aldol condensation, Rupe and Meyer&#8211;Schuster rearrangements and C&#8211;C coupling reactions (including a tandem Heck coupling&#8211;dehydrogenation). New processes for catalytic etherification, uncatalysed hydrogen transfer and a one-step arylamidation were also developed. Typical products were N-(4-hydroxyphenyl)acetamide, carvacrol, a-phenylacetamide, cinnamaldehyde, cinnamyl alcohol, acetophenone, indole, 3-hydroxy-1,2-dimethyl-4-pyridone, di(2-phenylethyl) ether, di(cyclopropylmethyl) ether, 3-methylcyclopent-2-enone and a synthetic precursor of nalidixic acid. 
