
%0 Journal Article
%A Cebon, Ben 
%A Lambert, John N. 
%A Leung, Donmienne 
%A Mackie, Hugh 
%A McCluskey, Karen L. 
%A Nguyen, Xuan 
%A Tassone, Claudia 
%T New DNA Modification Strategies Involving Oxime Formation
%J Australian Journal of Chemistry
%D 2000/07/21
%V 53
%N 4
%P 333-339
%K Conjugate; DNA; oligonucleotide; oxime; peptide; phosphoramidite; synthesis.
%R https://doi.org/10.1071/CH00018
%U https://www.publish.csiro.au/paper/CH00018 
%X A new method for the formation of covalently linked DNA conjugates is described. The method involves installation of a 5&acute;-hydroxylamine nucleophile onto synthetic DNA and condensation with a suitable electrophilic carbonyl compound to form an oxime linkage. Various protection strategies for the hydroxylamine group and their merits are discussed and the formation of an oligonucleotide&#8211;peptide conjugate is described. 
