
TY  - JOUR
A1  - Cebon, Ben 
A1  - Lambert, John N. 
A1  - Leung, Donmienne 
A1  - Mackie, Hugh 
A1  - McCluskey, Karen L. 
A1  - Nguyen, Xuan 
A1  - Tassone, Claudia 
T1  - New DNA Modification Strategies Involving Oxime Formation
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2000
VL  - 53
IS  - 4
SP  - 333
EP  - 339
KW  - Conjugate; DNA; oligonucleotide; oxime; peptide; phosphoramidite; synthesis.
UR  - https://doi.org/10.1071/CH00018 
N2  - A new method for the formation of covalently linked DNA conjugates is described. The method involves installation of a 5&acute;-hydroxylamine nucleophile onto synthetic DNA and condensation with a suitable electrophilic carbonyl compound to form an oxime linkage. Various protection strategies for the hydroxylamine group and their merits are discussed and the formation of an oligonucleotide&#8211;peptide conjugate is described. 
ER  -

