
%0 Journal Article
%A Lynch, Daniel E. 
%A Sandhu, Pardeep 
%A Parsons, Simon 
%T 1 : 1 Molecular Complexes of 4-Amino-<emph type="2">N</emph>-(4,6-dimethylpyrimidin-2-yl)benzene-sulfonamide (Sulfamethazine) with Indole-2-carboxylic Acid and 2,4-Dinitrobenzoic Acid
%J Australian Journal of Chemistry
%D 2000/07/27
%V 53
%N 5
%P 383-387
%K Sulfamethazine; carboxylic acid adducts; X-ray crystal structure.
%R https://doi.org/10.1071/CH00021
%U https://www.publish.csiro.au/paper/CH00021 
%X The 1 : 1 molecular adducts of 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide (Sulfamethazine) with respectively indole-2-carboxylic acid (1) and 2,4-dinitrobenzoic acid (2) have been prepared and their X-ray crystal structures determined. The acid groups in both structures form associative R22 (8) graph set hydrogen-bonding interactions across the N(11)&#8211;H/N(17) site of Sulfamethazine. Acomparison of the two distances between relevant non-hydrogen atoms in this configuration reveals that this association is not symmetrical. An average difference of 0.144 &#197; is observed for seven listed complexes of Sulfamethazine, five having been previously reported. This average difference compares with a value of 0.265 &#197; for the same interaction seen in carboxylic acid adducts of 2-aminopyrimidine. 
