
TY  - JOUR
A1  - Lynch, Daniel E. 
A1  - Sandhu, Pardeep 
A1  - Parsons, Simon 
T1  - 1 : 1 Molecular Complexes of 4-Amino-<emph type="2">N</emph>-(4,6-dimethylpyrimidin-2-yl)benzene-sulfonamide (Sulfamethazine) with Indole-2-carboxylic Acid and 2,4-Dinitrobenzoic Acid
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2000
VL  - 53
IS  - 5
SP  - 383
EP  - 387
KW  - Sulfamethazine; carboxylic acid adducts; X-ray crystal structure.
UR  - https://doi.org/10.1071/CH00021 
N2  - The 1 : 1 molecular adducts of 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide (Sulfamethazine) with respectively indole-2-carboxylic acid (1) and 2,4-dinitrobenzoic acid (2) have been prepared and their X-ray crystal structures determined. The acid groups in both structures form associative R22 (8) graph set hydrogen-bonding interactions across the N(11)&#8211;H/N(17) site of Sulfamethazine. Acomparison of the two distances between relevant non-hydrogen atoms in this configuration reveals that this association is not symmetrical. An average difference of 0.144 &#197; is observed for seven listed complexes of Sulfamethazine, five having been previously reported. This average difference compares with a value of 0.265 &#197; for the same interaction seen in carboxylic acid adducts of 2-aminopyrimidine. 
ER  -

