
TY  - JOUR
A1  - Sevillano, Paloma 
A1  - Habtemariam, Abraha 
A1  - Seijo, M. Inés García 
A1  - Castiñeiras, Alfonso 
A1  - Parsons, Simon 
A1  - García, M. Esther 
A1  - Sadler, Peter J. 
T1  - Homonuclear Pd<emph type="7">II</emph> and Pt<emph type="7">II</emph> and heteronuclear Pd<emph type="7">II</emph>-Au<emph type="7">I</emph> and Pt<emph type="7">II</emph>-Au<emph type="7">I</emph> complexes of a tripod triphosphine ligand: synthesis, characterization and reactions with molecules of biological relevance
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2000
VL  - 53
IS  - 8
SP  - 635
EP  - 644
KW  - Palladium; platinum; gold; phosphine; X-ray structures; n.m.r.; glutathione.
UR  - https://doi.org/10.1071/CH00028 
N2  - Complexes of the type Pd(tripod)X2 [tripod = MeC(CH2PPh2)3; X = Cl (1), Br (2), I (3)] and Pt(tripod)X2 [X = Cl (4), Br (5), I (6)] have been synthesized. In these complexes tripod acts as a bidentate chelating ligand. The uncoordinated phosphorus atom can bind to AuI to form the bimetallic complexes PdAu(tripod)X3 [X = Cl (7), Br (8), I (9)] and PtAu(tripod)X3 [X = Cl (10), Br (11), I (12)]. Complexes (1)&#x2013;(12) have been characterized by microanalysis, f.a.b. mass spectrometry, i.r. spectroscopy, 31P and 195Pt n.m.r. spectroscopies, and conductivity measurements. The structures of complexes (1), (4) and (11), as well as that of the unusual complex Cl2Pt(tripod)AuBr0.5Cl0.5 (13), isolated from reaction of Pt(tripod)Br2 (5), and [Au(thiodiglycol)Cl], have been determined. All complexes show square-planar geometry for PdII or PtII and linear geometry for AuI. The X-ray crystal structure of (1) showed partial oxidation of the dangling phosphorus of the ligand in 50% of the molecule distributed randomly over the lattice. Reactions of complex (4), Pt(tripod)Cl2, with the tripeptide glutathione (GSH) showed the formation of [Pt2(tripod)2(GS-&#xb5;&#x2013;S)2]2+ (15a). No reaction with N-acetyl-L-methionine (AcMet) or guanosine 5&#xb4;-monophosphate (5&#xb4;-GMP) was observed. Reactions of [Pt(tripod&#x2013;O)(ONO2)2] (14) with GSH resulted in the formation of [Pt2(tripod&#x2013;O)2(GS-&#xb5;-S)2]2+ (15b). Displacement of the S-containing molecules by 5&#xb4;-GMP in the presence of AuI, via Pt&#x2013;S bond cleavage, was observed for complex (15b). PtAu(tripod)Cl3 (10) reacted with GSH, with initial attack on the AuI centre. 
ER  -

