
TY  - JOUR
A1  - Kean, Suzanna D. 
A1  - Easton, Christopher J. 
A1  - Lincoln, Stephen F. 
T1  - Metallo-&#946;-cyclodextrins of 6<emph type="7">A</emph>-(2-(2-(2-Aminoethylamino)-ethylamino)ethylamino)-6<emph type="7">A</emph>-deoxy-&#946;-cyclodextrin and 6<emph type="7">A</emph>-Deoxy-6<emph type="7">A</emph>-(1,4,7,10-tetraazacyclododecan-1-yl)-&#946;-cyclodextrin: Their Formation and Complexation of (<emph type="3">R</emph>)- and (<emph type="3">S</emph>)-Tryptophan and Tryptophanate in Aqueous Solution
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2000
VL  - 53
IS  - 5
SP  - 375
EP  - 381
KW  - Copper; cyclodextrin; nickel; stability constant; tryptophan; tryptophanate; zinc.
UR  - https://doi.org/10.1071/CH00052 
N2  - The binary metallo-&#946;-cyclodextrins formed by 6A-(2-(2-(2-aminoethylamino)ethylamino)ethylamino)-6A-deoxy-&#946;-cyclodextrin, &#91;M(&#946;CDtrien)&#93;2+, where M2+ = Ni2+, Cu2+ and Zn2+, are characterized by log(K/dm3 mol-1) = 11.500.02, 10.700.07 and 9.400.01, respectively, in aqueous solution at 298.2 K and I = 0.1 mol dm-3 (NaClO4), where K is the stability constant. For those formed by 6A-deoxy-6A-(1,4,7,10-tetraazacyclododecan-1-yl)-&#946;-cyclodextrin, &#91;M(&#946;CDcyclen)&#93;2+, where M2+ = Cu2+ and Zn2+, log(K/dm3 mol-1) = 13.610.02 and 11.620.04, respectively. The ternary metallo-&#946;-cyclodextrins formed by &#91;M(&#946;CDtrien)&#93;2+ and (R)- and (S)-tryptophanate, &#91;M(&#946;CDtrien)((R)-Trp)&#93;+ and &#91;M(&#946;CDtrien)((S)-Trp)&#93;+ are characterized by log(K/dm3 mol-1) = 6.900.04 and 6.790.04, 8.20.3 and 7.90.2, and 6.640.08 and 7.010.07, respectively, where M2+ = Ni2+, Cu2+ and Zn2+. For the ternary metallo-&#946;-cyclodextrins formed by &#91;M(&#946;CDcyclen)&#93;2+ and (R)- and (S)-tryptophanate, &#91;M(&#946;CDcyclen)((R)-Trp)&#93;+ and &#91;M(&#946;CDcyclen)((S)-Trp)&#93;+, log(K/dm3 mol-1) = 6.840.06 and 6.850.06, and 4.950.05 and 4.940.04, respectively, where M2+ = Cu2+ and Zn2+. Other binary and ternary metallo-&#946;-cyclo-dextrins are also formed. Binary complexes formed by the substituted &#946;-cyclodextrins are exemplified by &#946;CDcyclen.(R)-Trp- and &#946;CDcyclen.(S)-Trp- for which log(Kd/m3 mol-1) = 3.690.04 and 3.950.03, respectively. These data are discussed together with those from the literature characterizing other metallo-&#946;-cyclodextrin and substituted &#946;-cyclodextrin systems. 
ER  -

