
%0 Journal Article
%A Wilson, J. Gerald 
%A Katsifis, Andrew G. 
%T Phenolic Analogues of Amino Carboxylic Acid Ligands for <emph type="7">99m</emph>Tc. V.<emph type="2">N</emph>-Benzyl-2-(2-hydroxyphenyl)glycines (bhpg) and <emph type="2">N</emph>-Benzyl-2-(4-hydroxyphenyl)glycines (isobhpg)
%J Australian Journal of Chemistry
%D 2000/10/27
%V 53
%N 7
%P 583-587
%K Phenols; benzylamine; glyoxylic acid; glycine; Mannich reaction; hepatobiliary agents.
%R https://doi.org/10.1071/CH00054
%U https://www.publish.csiro.au/paper/CH00054 
%X A series of tridentate ligands, N-benzyl-2-(2-hydroxyphenyl)glycines (bhpg) (4), were prepared by the Mannich reaction of phenol and a number of para-substituted phenols with glyoxylic acid and benzylamine. When the two ortho positions of the phenol were blocked, as in the case of 2,6-dimethyl and 2,6-dichloro phenols, the isomeric compounds N-benzyl-2-(4-hydroxyphenyl)glycines (isobhpg) (5) were formed. When the phenol had one ortho substituent, as in the case of o-cresol and o-chlorophenol, both isomers were isolated. Two examples of the use of the chiral &#945;-phenylethylamine in place of benzylamine are described. 
