
TY  - JOUR
A1  - Wilson, J. Gerald 
A1  - Katsifis, Andrew G. 
T1  - Phenolic Analogues of Amino Carboxylic Acid Ligands for <emph type="7">99m</emph>Tc. V.<emph type="2">N</emph>-Benzyl-2-(2-hydroxyphenyl)glycines (bhpg) and <emph type="2">N</emph>-Benzyl-2-(4-hydroxyphenyl)glycines (isobhpg)
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2000
VL  - 53
IS  - 7
SP  - 583
EP  - 587
KW  - Phenols; benzylamine; glyoxylic acid; glycine; Mannich reaction; hepatobiliary agents.
UR  - https://doi.org/10.1071/CH00054 
N2  - A series of tridentate ligands, N-benzyl-2-(2-hydroxyphenyl)glycines (bhpg) (4), were prepared by the Mannich reaction of phenol and a number of para-substituted phenols with glyoxylic acid and benzylamine. When the two ortho positions of the phenol were blocked, as in the case of 2,6-dimethyl and 2,6-dichloro phenols, the isomeric compounds N-benzyl-2-(4-hydroxyphenyl)glycines (isobhpg) (5) were formed. When the phenol had one ortho substituent, as in the case of o-cresol and o-chlorophenol, both isomers were isolated. Two examples of the use of the chiral &#945;-phenylethylamine in place of benzylamine are described. 
ER  -

